Abstract: OBJECTIVE To investigate the effectiveness of risk control model nursing for the prevention of chemotherapy infections in children with leukemia admitted to sterile laminar flow wards. METHODS Totally 126 children diagnosed with acute leukemia who received chemotherapy in Shengjing Hospital of China Medical University from Jun.2019 to Jun.2022 were selected as the study subjects, and randomly divided into a study group and a control group, with 63 cases in each group.Children in control group received routine care, children in the study group received the risk control model of care on the basis of the control group.The incidence of infection, the length of hospitalization, the duration of antimicrobial drug use and the satisfaction of the family members of the children were compared between the two groups. RESULTS The infection rate of children in the study group was 22.22% (14/63), lower than that in the control group (P=0.001); the length of hospitalization and the duration of antimicrobial drug use in the study group were significantly shorter than those in the control group(P＜0.05); the satisfaction rate of the study group was better than that of the control group (P=0.020). CONCLUSION The application of risk control model nursing in the admission of children with acute leukemia to a sterile laminar flow wards for chemotherapy treatment could effectively reduce the incidence of infection and improve the satisfaction of children's family members.