Abstract: OBJECTIVE To investigate the role of quality control circle（QCC） activities in reducing ventilator-associated pneumonia（VAP） in intensive care unit（ICU） patients. METHODS Inpatients in ICU of Jiaozhou Central Hospital in Qingdao were selected as the research subjects. Totally 102 inpatients from July to September 2017 were selected as the control group. QCC activities were implemented in October 2017. 156 hospitalized patients from October 2017 to March 2018 were included in the study group. The incidence of VAP was compared between the two groups. RESULTS After the implementation of the quality control circle activities, the implementation rate of various infection prevention and control measures increased from 62.41%（953/1 527） before the event to 96.21%（1 498/1 557）, and the incidence of VAP decreased from 49.66 ‰（22/443）before the event to 13.06 ‰（9/689）after the event, and the difference was significant（P＜0.001）. The target achievement rate was 126.78%, and the improvement rate was 73.70%. The quality control circle had improved the application of management tools, problem-solving ability, scientific research ability and team spirit et al. to varying degrees. CONCLUSION The QCC activity effectively reduced the incidence of VAP in patients in the intensive care unit（ICU）, enhanced the awareness of medical staff to prevent VAP, which achieved the goal of continuous quality improvement and had a good effect on improving medical quality.