OBJECTIVE To investigate the relationship between Helicobacter pylori (Hp) infection and non-alcoholic fatty liver disease (NAFLD), glycolipid metabolism and serum inflammatory factor.

METHODS The clinical data of 386 people under physical examination in the First People′s Hospital of Linhai from Sep 2020 to Sep 2022 were retrospectively analyzed. They were divided into the Hp-positive group (124 cases, ¹³C urea breath test positive reference value ≥4) and the Hp-negative group (262 cases, ¹³C urea breath test positive reference value < 4) according to the results of ¹³C urea breath test. The general data, glycolipid metabolism, liver function indicators and inflammatory factors were compared between the two groups, and the risk factors for Hp infection were analyzed by multifactor logistic regression.

RESULTS The incidence of NAFLD in the Hp-positive group was 44.35%, which was higher than that in the Hp-negative group (24.05%, P < 0.05). The levels of fasting glucose (FPG), fasting insulin (FINS), 2 hour postprandial plasma glucose(2hPPG), homeostasismodel assessment-IR (HOMA-IR) and levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) in the Hp-positive group were higher than those in the Hp-negative group (P < 0.05); the serum level of high density lipoprotein cholesterol (HDL-C) was lower than that in the Hp-negative group (P < 0.05). Multivariate logistic regression analysis showed that NAFLD, high expression of whole blood FPG, 2hPPG, serum LDL-C, TG, IL-6, IL-10, TNF-α, IFN-γ and low expression of serum HDL-C were risk factors for Hp infection (P < 0.05).

CONCLUSION Hp infection was associated with NAFLD and can cause glycolipid metabolism disorders and abnormal changes in serum inflammatory factors, which can be reference for clinical screening and treatment of Hp infection timely.