Abstract: OBJECTIVE To explore the effective measures for improvement of hand hygiene compliance of the health care workers so as to continuously improve the hand hygiene. METHODS The PDCA cycle management mode was employed to conduct the continuous quality improvement of hand hygiene of the health care workers, the weak links of the management were found out in a timely manner through 4 stages, including plan, do, check, and action so as to make continuous improvement.A total of 185 health care workers were recruited to conduct a randomized test of the concept of hand hygiene, hand hygiene, hand disinfection indications, correct hand washing methods, and self protection; the test results were input into the Excel 2003 software, the statistical analysis was performed with the use of SPSS 13.0 software, and the chi-square test was adopted. RESULTS The awareness rate of hand hygiene knowledge of the health care workers of the general surgery department remarkably increased from 55.67% before the implementation of PDCA cycle to 95.97% after the implementation of PDCA cycle, the qualified rate of hand hygiene increased from 61.19% to 97.41%, the hand washing compliance increased from 38.82% to 90.55%, and there was significant difference in the status of hand hygiene before and after the implementation of PDCA cycle. CONCLUSION The PDCA cycle is applied in the continuous quality improvement, which can effectively improve the hand hygiene compliance of the health care workers.