Abstract: OBJECTIVE To observe the variation in blood pressure and the occurrence of adverse reactions in the elderly people before and after inoculation of the COVID-19 inactivated vaccine. METHODS Total of 651 participants aged less than 60-years were retrospectively analyzed. They were under a comprehensive assessment（such as medical history, allergic history） before the first dose of vaccination, and those with vaccination contraindications were excluded. Qualified candidates were selected to receive two doses（0.5 ml each, interval 21 days） of the COVID-19 inactivated vaccine. Blood pressure was measured before inoculation and 30 minutes later to observe the changes of blood pressure. Vaccine-related side effects were followed up, and the effect of inactivated the COVID-19 vaccination on blood pressure in the elderly population was analyzed. RESULTS The COVID-19 inactivated vaccine showed no significant effects on blood pressure after inoculation in the people over 60 years old. Significant hypotension and hypertension have not be observed in people with hypertension history after inoculation, and no severe adverse reactions were reported after inoculation, only 4 cases of minor adverse reactions were collected. CONCLUSION Inoculation of the COVID-19 inactivated vaccine has no significant effect on blood pressure in the elders. Furthermore, the incidence of adverse reactions to the vaccination is low in the elderly people, supporting the comprehensive promotion of population over 60 years old with steady health conditions receiving the inoculation.