Abstract: OBJECTIVE To explore the effects of nursing intervention on reducing postoperative pulmonary infections of gastric and duodenal perforation and improving patients' hospitalized satisfaction. METHODS One hundred and thirty five patients with gastric and duodenal perforation from Mar. 2014 to Jan. 2016 were selected, and were randomly divided into observation group (68 cases) and control group (67 cases). The former were given nursing intervention and the later only received regular nursing care. The patients' pulmonary infection rates and hospitalized satisfaction were compared between the two groups. RESULTS Totally 7 cases occurred pulmonary infection in observation group, and the infections rate was 10.3%. By sputum culture, 8 strains of bacteria were detected, which were mainly 6 strains (75.0%) of gram-negative bacteria. The infection rate of control group was 26.9%, and 20 strains of bacteria were isolated, which were mainly 15 strains (75.0%) of gram-negative bacteria. There was significant difference between the two groups in the pulmonary infection rate (P<0.05). The patients average hospitalized satisfaction of observation group was 95.6%, which was higher than 85.1% of control group(P<0.05). CONCLUSION Postoperative nursing intervention can reduce the risk of pulmonary infections in patients with gastric and duodenal perforation, which is beneficial for rehabilitation of patients and improving patients hospitalized satisfaction.