Abstract: OBJECTIVE To analyze the related risk factors for surgical site infections in patients of general surgery department so as to provide scientific basis for clinical prevention and treatment of the patients with surgical site infections. METHODS The clinical data were collected from 430 patients who underwent surgeries in the general surgery department from Sep 2012 to Sep 2014, then the major risk factors were screened out, the correlation between the risk factors and the surgical site infections was observed, the specimens were collected from the patients with suspected incision infections so as to conduct the etiological culture, the drug susceptibility testing was performed, and the statistical analysis of data was performed with the use of SPSS 12.0 software and EXCEL software. RESULTS Of the 430 patients, 21 had surgical site infections with the incidence rate of 4.9%. Among the isolated pathogens, 71.4% were gram-negative bacteria, 19.0% were gram-positive bacteria, and 9.6% were fungi. The related risk factors for the surgical site infections included the age, genders, diabetic mellitus, types of surgical incision, operation duration, obesity, perioperative anemia, malnutrition, preoperative hair removing, and timing of surgery. CONCLUSION It is an effective way to strengthen the awareness and management of the risk factors for the surgical site infections and take the preventive measures so as to reduce the incidence of the surgical site infections in the patients of the general surgery department.