Abstract: OBJECTIVE To observe the application effect of cluster management measures on patients with PICC-related bloodstream infection. METHODS A total of 150 tumor patients who were treated with PICC in the hospital from May 2013 to May 2016 were recruited as the study objects.The incidence of PICC-related bloodstream infection was analyzed after the cluster management.The enrolled patients were divided into the conventional group and the cluster group, with 75 cases in each group.The conventional group was treated with traditional method, while the cluster group was treated with cluster management of PICC.The incidence of PICC-related bloodstream infection and utilization rate of PICC were observed. RESULTS The catheter indwelling time of the cluster group was (236.43±10.12) days, shorter than (238.67±9.35) days of the conventional group, and there was no significant difference between the two groups (t=1.4080,P=0.1612).The mean duration of catheterization of the cluster group was (136.43±10.49) days, longer than (88.45±9.12) days of the conventional group, and there was significant difference between the two groups (P＜0.05).The mean hospitalization duration of the cluster group was (236.43±8.49) days, the conventional group (257.02±10.37) days, and there was significant difference between the two groups (P＜0.05).Only 4 patients had catheter-related bloodstream infection (CRBSI) in the cluster group, with the incidence rate 12.70‰; 18 patients had CRBSI in the conventional group, with the incidence rate 33.51‰, and there was significant difference between the two groups (P＜0.05).The utilization rate of catheters was 53.12% in the cluster group, 33.84% in the conventional group, and there was significant difference between the two groups (P＜0.05). CONCLUSION The cluster management may remarkably raise the utilization rate of PICC and reduce the incidence of PICC-related bloodstream infection, and it is worthy to be promoted in the hospital.