Abstract: OBJECTIVE To analyze the effect of H. pylori（HP） infection on blood glucose and lipid metabolism in patients with metabolic syndrome.METHODS Using prospective analysis research methods, 1 196 patients with metabolic syndrome who were treated in the Affiliated Hospital of Jining Medical College from Nov. 2017 to Nov. 2020 were studied. According to the results of ¹⁴C urea breath test, 1 196 patients with metabolic syndrome were divided into Hp positive group（n=498） and Hp negative group（n=698）. The levels of blood lipid and blood glucose-related indicators of the two groups were compared, the abnormal rates of blood lipid and blood glucose and other clinical data of the two groups were compared, and the influencing factors of Hp positive were analyzed by multivariate analysis.RESULTS The body mass index（BMI）, triglyceride, total cholesterol and low-density lipoprotein cholesterol（LDL-C） of the Hp positive group were signigifcantly higher than those of the Hp negative group（P＜0.05）. Serum glucose（GLU）, fasting blood glucose（FBG）, 2 h postprandial blood glucose（2 H PG）, HbA1 c and fasting insulin（FINS） levels in the Hp positive group were signigifcantly higher than those of the Hp-negative group（P＜0.05）. The abnormal rate of BMI, triglyceride, total cholesterol, LDL-C, GLU, FBG, 2 H PG, HbA1 c and FINS in the Hp positive group were signigifcantly higher than those of the Hp-negative group（P＜0.05）. The body mass, waist circumference, hip circumference and WHR of the Hp positive group were signigifcantly higher than those of the Hp-negative group（P＜0.05）. In the regression process, the stepbackward method was adopted to select and eliminate the independent variables, with elimination =0.10 and inclusion =0.05. The regression results suggested that BMI, triacylglycerol, GLU, and FBG were the influencing factors of Hp positive（P＜0.05）.CONCLUSION Hp infection could aggravate the disorder of blood glucose and blood lipid metabolism in patients with metabolic syndrome, increase the incidence of abnormalities of blood lipid and blood glucose, and the disorder of blood glucose and lipid metabolism was also influencing factors for Hp infection.