基于多层螺旋计算机断层摄影技术的水痘肺炎自动诊断系统构建及其应用

Establishment of automatic diagnosis system for varicella pneumonia based on multi-slice spiral computed tomography and its application

  • 摘要:
    目的 构建基于多层螺旋计算机断层摄影技术(MSCT)的水痘肺炎自动诊断系统, 并验证其应用价值。
    方法 回顾性分析2016年1月-2023年3月医院收治的295例水痘患者临床资料作为训练集, 收集其MSCT胸部扫描检查获得的肺部影像诊断肺炎。采用卷积神经网络技术构建基于MSCT的水痘肺炎自动诊断系统。另回顾性分析同期收治的279例水痘患者资料作为验证集, 以综合诊断结果为金标准, 分析上述系统对水痘肺炎的诊断效能。
    结果 验证集水痘患者共279例, 243例为水痘肺炎, 36例单纯水痘感染。基于MSCT的水痘肺炎自动诊断系统对验证集水痘肺炎的诊断灵敏度(97.53%)、特异度(91.67%)和准确度(96.77%)高于MSCT(灵敏度93.83%, 特异度83.33%, 准确度92.47%), 且与金标准一致性高(Kappa=0.919, P<0.001), MSCT与金标准结果也存在一致性(Kappa=0.675, P<0.001)。
    结论 基于MSCT的水痘肺炎自动诊断系统可提高对水痘肺炎的诊断灵敏度、特异度和准确度,且有自动化、便利等优势, 为医师诊断水痘肺炎提供了新的工具。

     

    Abstract:
    OBJECTIVE To establish the automatic diagnosis system for varicella pneumonia based on multi-slice spiral computed tomography (MSCT) and verify its application value.
    METHODS The clinical data were collected from 295 patients with varicella who were treated in the hospital from Jan. 2016 to Mar. 2023 and assigned as the training set, the pulmonary imaging findings were acquired from the MSCT chest scanning. The automatic diagnosis system for varicella pneumonia was established based on MSCT with the use of convolutional neural network technology. Totally 279 patients with varicella who were treated during the same period were chosen as the validation set, the result of comprehensive diagnosis was set as gold standard, and the efficiency of the above system in diagnosis of varicella pneumonia was observed.
    RESULTS Totally 279 patients with varicella were included in the validation group, 243 of whom had varicella pneumonia, and 36 had simple varicella infection. The sensitivity of the automatic diagnosis system established based on MSCT was 97.53% in diagnosis of the varicella pneumonia of the validation group, with the specificity 91.67%, the accuracy 96.77%, respectively higher than 93.83%, 83.33% and 92.47% of MSCT, and it was highly consistent with the gold standard(Kappa=0.919, P < 0.001); there was consistency between MSCT and the gold standards(Kappa=0.675, P < 0.001).
    CONCLUSION The automatic diagnosis system for varicella pneumonia established based MSCT can raise the sensitivity, specificity and accuracy in diagnosis of varicella pneumonia and have the advantages of automation and convenience, and serve as a new tool for clinical diagnosis of varicella pneumonia.

     

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