Fatal risk factors for non-Hodgkin lymphoma patients with febrileneutropenia developing infection after chemotherapy

OBJECTIVE To analyze the fatal risk factors for non-Hodgkin lymphoma（NHL）patients with febrile neutropenia developing infection after chemotherapy,so as to provide clinical evidence for treating NHL patients with febrile neutropenia after chemotherapy.METHODS A total of 123 NHL patients with febrile neutropenia who were hospitalized and received chemotherapy at the SUN Yat-sen University Cancer Center from Mar.2012 to Nov.2014 were retrospectively analyzed.Through querying the electronic medical records,clinical data of age,gender,tumor staging and so on were collected.Univariate analysis was done to analyze all the risk factors,and significant variables were selected and used in multivariate and unconditioned logisticregression analysis,in order to obtain the independent fatal risk factors for NHL patients with febrile neutropenia developing infection after chemotherapy.RESULTS The overall intra-hospital mortality was 18.7%（23cases）.For univariate analysis,there were significant differences in the mortality rates according to ICU admission,PCT（procalcitonin）＞ 2ng/ml,duration of gradeⅣ myelosuppression ＞ 10 days,and multi-site hospital infection.In multivariate and unconditioned logistics regression analysis,PCT ＞ 2ng/ml and duration of grade Ⅳ myelosuppression ＞ 10 days were the independent fatal risk factors for NHL patients with febrile neutropenia developing infection after chemotherapy.CONCLUSION NHL patients with febrile neutropenia developing infection after chemotherapy have high intra-hospital mortality,and the early diagnosis of infection and actively treating bone marrow suppression could have contributed to improve the survival of such patients.