Nerve involvement in treatment of intracranial infection pathogenic bacteria distribution and drug susceptibility analysis

OBJECTIVE Interventional treatment from hair nerve distribution intracranial infection pathogens and drug sensitivity of the investigation and analysis,to provide reference evidence for clinical treatment.METHODS Select the hospital in August 2010- October 2015 nerve involvement after intracranial infection in patients treated845 cases,spinal puncture to obtain cerebrospinal fluid specimens using Vitek 2Compact type of bacteria identification.RESULTS 276 pathogens isolated were gram-negative bacteria 131,accounting for 47.46%,Acinetobacter baumannii 47（17.03%）,Klebsiella pneumoniae 28（10.14%）,Pseudomonas aeruginosa 21（7.61%）;grampositive bacteria 93,accounting for 33.69%,Staphylococcus aureus 32（11.6%）,Staphylococcus epidermidis 24（8.70%）;fungi 52,accounting for 18.84%,mainly Cryptococcus neoformans 46（16.67%）.Resistance rates of A.baumannii,P.aeruginosaand K.pneumoniae resistance rates to ampicillin,penicillin were 100.0%,and K.pneumoniae resistance rate to imipenem was 8.9% and 5.6%.Resistance rates of S.aureus and Staphylococcus epidermidis to penicillin,cefoxitin were 100.0%.C.neoformans did show resistance to voriconazole,fluconazole,amphotericin B.CONCLUSION Gram-negative bacteria are the main pathogens in neurology intervention in patients with intracranial infection,drug resistance to a variety of infections is higher.