Drug sensitivity and preventive measures in patientswith pulmonary tuberculosis and fungal infection

OBJECTIVE To investigate the drug sensitivity of tuberculosis fungal infection cases,so as to provide guidance for preventive measures.METHODS A total of 116 cases of tuberculosis patients from May 2013 to Sep.2015 admitted to hospital,who were divided into secondary fungal infection group and pure tuberculosis group,each with 58 cases.The fungal infection types in patients were under statistical analysis and susceptibility test.The drug-resistant infection rate and risk factors for infection were analyzed to explore the relevant treatment options and preventive measures.RESULTS The infection site of 58 cases of pulmonary tuberculosis fungal infections was mainly respiratory tract.There were 72 strains of fungi cultured from the sputum,in which Candida albicans44 strains accounting for 61.11%,Glabrata11 strains 15.28%,Candida tropicalis 8strians 11.11%,Candida parapsilosis 3strains 4.17%,Aspergillus 6strains 8.33%.Candida albicans and Candida glabrata had resistance rates less than 10.00% to 5-fluoro-cytosine,iraq itraconazole,voriconazole,fluconazole,amphotericin B.Candida tropicalis had 0.00% resistant to amphotericin B,but to 5-fluoro cytosine,itraconazole,voriconazole,fluconazole more than 10.00%,in which the fluconazole reached 50.00%.Two groups of the patients hospital stay,course of the disease,invasive procedures in treatment,complicated and antimicrobial drug prevention had significant difference（P＜0.05）.CONCLUSION There were various fungal infection types in patients with tuberculosis,and Candida albicans is the most common one.The analyzes of clinical fungal infection rate and risk factors for infection resistant to clinical treatment and preventive measures have a certain significance.