Clinical correlation analysis of different times of theuse of antibiotics and infection after spine surgery

OBJECTIVE To study the correlation between time of the use of antibiotics and infection after spine surgery,so as to provide evidences for clinic prevention of infection after spinal surgery.METHODS A total of 150 cases of patients underwent spinal surgery in the hospital from Jan.2013 to Dec.2015 were selected as the objects of study,and were divided into two groups according to the different times of the use of antimicrobial agents in the surgery.Patients of group A（70cases）,were given antibiotics half an hour before surgery and did not take antibiotics after surgery,and patients of group B（80cases）were given 3days of antibiotics after surgery and without preoperative use of antibiotics.RESULTS A postoperative infection rate of group A and B were 7.1% and 16.3%,with significant difference（P＜0.05）.The usage time of antibiotics,postoperative fever clearance time,hospitalized time and treatment costs of group A were（1.1±0.3）d,（1.3±0.4）d,（11.7±3.2）d,（2643.8±321.8）yuan,of group B were（3.4±0.8）d,（2.7±0.6）d,（18.2±4.1）d,（3174.5±355.1）yuan,and differences two sets of data were significant（P＜0.05）.CONCLUSION The perioperative use of antimicrobial drugs at different times during clinical spine surgery has some influence on the infection after surgery.Taking antimicrobial drugs half an hour before surgery can better prevent postoperative infections and shorten the length of hospital stay of patients.