Distribution and drug resistance of pathogens causing respiratory tract infections in patients with tuberculosis

OBJECTIVE To explore the distribution and drug resistance of pathogens causing infections in patients with tuberculosis.METHODS A total of 119 patients with tuberculosis who were treated from Mar 2014 to Mar 2014 were recruited as the study objects, the incidence of respiratory tract infections was analyzed, and the constituent ratios of the pathogens causing the infections and the drug susceptibility rates were observed.RESULTS Of the 119 patients with tuberculosis, 67 were complicated with respiratory tract infections, with the infection rate 56.30%. Totally 96 strains of pathogens were isolated from the 67 patients with the infections, 62 (64.58%) of which were gram-negative bacteria, 26 (27.08%) were gran-positive bacteria, and 8 (8.34%) were fungi; Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae were dominant among the gram-negative bacteria; Staphylococcus aureus and Staphylococcus epidermidis were the predominant species of the gram-positive bacteria. The drug resistance rates of the P.aeruginosa strains to cefepime, cefoperazone, imipenem, meropenem and aztreonam were low; the drug resistance rates of the K.pneumoniae strains to amikacin, cefoperazone, imipenem and meropenem were low; the drug resistance rates of the S.aureus strains to linezolid, erythromycin, vancomycin, sulfamethoxazole-trimethoprim and tigecycline were low; the drug resistance rates of the S.epidermidis strains to vancomycin, erythromycin, nitrofurantoin and sulfamethoxazole-trimethoprim were low; the drug resistance rates of Candida albicans and Candida tropicalis to amphotericin B were 0%.CONCLUSION The patients with opportunistic infections caused by the gram-negative bacteria are dominant among the tuberculosis patients with secondary respiratory tract infection and are characterized by high drug resistance and multi-drug resistance.HT5"SS It is necessary for the hospital to reasonably use antibiotics based on the results of the drug susceptibility testing.