Distribution and drug resistance of pathogens causing infections in patients with infectious ophthalmopathy

OBJECTIVE To explore the distribution and drug resistance of pathogens causing infections in patients with infectious ophthalmopathy so as to provide guidance for clinical diagnosis and treatment.METHODS A total of 2218 patients with infectious ophthalmopathy who were treated in the hospital from Jan 2012 to Dec 2016 were recruited as the study objects, the pathogens that were isolated from the eye site specimens were identified, and the drug susceptibility testing was performed by using K-B disk diffusion method.RESULTS Of the 2418 eye site specimens, 733 were cultured positive, with the positive rate 30.31%. Totally 733 strains of pathogens were isolated, 503 of which were gram-positive bacteria, 111 were gram-negative bacteria, and 119 were fungi; there were 224 strains of Staphylococcus aureus and 119 strains of Corynebacteria among the gram-positive bacteria; there were 59 strains of Pseudomonas aeruginosa among the gram-negative bacteria; there were 86 strains of Fusarium and 21 strains of Aspergillus among the fungi. The positive specimens were mainly obtained from the patients with infections induced by foreign body penetration, keratohelcosis and chemical burns. The drug susceptibility rates of the Staphylococcus spp strains to vancomycin, fusidic acid, levofloxacin and azithromycin were 100.00%, 93.06%, 85.22% and 76.26%, respectively; the drug susceptibility rates of the Corynebacteria strains to vancomycin, levofloxacin, gentamicin and tobramycin were 100.00%, 93.12%, 87.05% and 91.03%, respectively.CONCLUSION The gram-positive bacteria are dominant among the pathogens isolated from the patients with infectious ophthalmopathy, most of which are highly susceptible to vancomycin, fusidic acid and levofloxacin. It is necessary for the hospital to choose the above antibiotics for treatment of the patients with infectious ophthalmopathy so as to improve the curative effect.