Distribution and drug resistance of pathogens causing respiratory tract infections in children and serum immunological indexes

OBJECTIVE To investigate the distribution and drug resistance of pathgoens causing respiratory tract infections in children and observe the changes of levels of immunological indexes of the children with infections so as to provide guidance for clinical treatment.METHODS Totally 290 children with respiratory tract infections who were treated in hospitals from Mar 2014 to Mar 2017 were chosen as the group A, meanwhile, 290 healthy children who received physical examination were set as the group B. The sputum specimens and respiratory tract secretions were collected from the children with respiratory tract infections, the isolated pathogens were identified, the drug resistance was determined by using K-B method, and the immunoglobulins were detected with the use of immuno-scatter turbidimetry.RESULTS Among the gram-positive bacteria, the drug resistance rates of Staphylococcus aureus and Streptococcus pneumoniae strains to ampicillin-sulbactam, penicillin G, piperacillin, levofloxacin and cefuroxime sodium were more than 50%. Among the gram-negative bacteria, the Escherichia coli strains were highly resistant to ampicillin, cefuroxime, nitrofurantoin, aztreonam, ciprofloxacin, gentamicin, cefazolin and ceftazidime. The levels of LgG2, LgG4 and LgM of the group A were respectively (1.82±0.53),(0.23±0.19) and(1.01±0.47), lower than (2.74±0.88),(0.61±0.39) and (1.85±0.56) of the group B; the LgE level of the group A was (1.89±0.32), higher than (1.17±0.35) of the group B (P＜0.05).CONCLUSION The gram-negative bacteria such as Klebsiella pneumoniae and E.coli are dominant among the pathogens causing the respiratory tract infections in the children, the drug resistance rates of the above species to cefoperazone-sulbactam, meropenem and imipenem are low. The respiratory tract infections in the children are associated with the immune dysfunction. LgG2, LgG4, LgM and LgE can be served as the major indexes for immune function examination of the children with respiratory tract infections.