Meta analysis of risk factors of hospital-acquired pneumonia caused by carbapcnem-resistant Acinetobacter baumannii

OBJECTIVE To synthetically evaluate the risk factors of hospital-acquired pneumonia(HAP) caused by carbapcnem-resistant Acinetobacter baumannii (CRAB) in China. METHODS The relative researches of HAP caused by CRAB were searched by domestic and abroad literature database from Jan. 1,2000 to Nov. 30,2017. The clinical data that conformed to the standard were selected. Data extraction and comprehensive analysis of selected literatures were carried out by meta analysis. RESULTS Totally 17 relative literatures were selected in this study, including 2340 patients. Among eleven risk factors, seven factors had statistical significances, which were using hormone(OR=1.89,95%CI=1.47~2.43),mechanical ventilation(OR=4.13,95%CI=3.38~5.05),using deep venous catheterization(OR=2.11,95%CI=1.40~3.19),use of more than three antibiotics(OR=3.58,95%CI=2.12~6.06),using antibiotics more than a week(OR=5.13,95%CI=2.62~10.04),use of carbapenems antibiotics before the infection(OR=5.46,95%CI=3.52~8.46), and stay in ICU more than 7 days(OR=4.84,95%CI=1.54~15.19). CONCLUSION It is necessary to take effective measures according to the related risk factors so as to reduce and prevent HAP caused by CRAB.