Analysis of clinical risk factors for Corynebacterium striatum respiratory tract infection

OBJECTIVE To explore the clinical risk factors for respiratory tract infection of Corynebacterium striatum, and to establish the awareness of infection prevention and control, reducing the occurrence of respiratory tract infection of C. striatum. METHODS The data of 213 patients infected with C. striatum in the Affiliated Hospital of North China University of Science and Technology from Oct 2017 to Jan 2018 were retrospectively analyzed, and the distribution characteristics of clinical departments and the risk factors for the bacteria were statistically analyzed. RESULTS The infected patients were mainly from the ICU and neurosurgical wards, which were divided the pathogenic group and colonization group. The mortality in the pathogenic group was higher than that in the colonization group（P＜0.05）. Univariate analysis showed that age, diseases of blood system, digestive system, respiratory system and nervous system, trauma, infection of malignant tumor, hypoalbuminemia use of hormone, infection before the use of antifungal drugs, invasive operation in lien invasive devices, central venous catheter indwelling time, chest wear, waist, tracheotomy, breathing machine auxiliary mechanical ventilation, surgery and infection before ICU admission were risk factors for respiratory morbidity of C. striatum. Multivariate analysis showed that pre-infection hormone use（OR=0.197,P=0.002）, hypoproteinemia（OR=0.287,P=0.032）, lumbar puncture（OR=0.035,P=0.004） and tracheotomy（OR=13.594,P＜0.001） were risk factors for respiratory tract infection caused by C. striatae. CONCLUSION Patients with low immunity who use hormones for a long time and have invasive operations are prone to cause C. striatum infection in the respiratory tract. Early prevention can reduce the incidence of C. striatum infection and death.