Analysis of pathogenic distribution of bacteria and evolution of drug-resistant strain spectrum in patients with cerebral infarction from 2011 to 2020

OBJECTIVE To analyze the pathogenic bacteria detected in patients with cerebral infarction infection in the department of neurology and the evolution of main drug-resistant bacteria in 10 years. METHODS Patients diagnosed with cerebral infarction in the First Medical Center of PLA General Hospital from Jan 1, 2011 to Dec 31, 2020 were recruited. The basic information, pathogen names and drug-resistant bacteria of infected patients were registered, and the variation in 10 years were analyzed by statistical software. RESULTS A total of 3250 strains of pathogenic bacteria were detected from 1660 patients with secondary infection in 853 cases, including 1868 strains of gram-negative bacteria（57.48%）, 712 strains of fungi（21.91%） and 670 strains of gram-positive bacteria（20.62%）. The analysis showed that gram-negative bacteria were always the main bacteria detected in patients with cerebral infarction in the past 10 years. The detection rate of multidrug-resistant Acinetobacter baumannii was 33.85%, and the detection situation of drug-resistant bacteria changed significantly in 10 years. CONCLUSION The pathogen of nosocomial infection in cerebral infarction patients admitted in neurology department is mainly gram-negative bacteria. The analysis of the evolution of drug-resistant bacteria spectrum in 10 years can provide reference for the prevention and empirical antibacterial treatment of cerebral infarction infection.