Expressions of AQ94 and S100β genes in infectious hydrocephalus and clinical significance

OBJECTIVE To analyze the expressions of aquaporin 4 (AQP4) and central nervous system specific protein (S100 β) genes in infectious hydrocephalus and observe the clinical significance. METHODS A total of 120 patients with hydrocephalus who were treated in the Affiliated Hospital of Qingdao Binhai University and People's Hospital Affiliated to Shandong First Medical University from Sep 2019 to Mar 2021 were recruited as the research subjects and divided into the infection group with 49 cases and the no infection group with 71 cases according to the status of bacterial infection. The expression of AQP4 was detected by fluorescent quantitative polymerase chain reaction (PCR), the expression of S100β was detected by enzyme-linked immunosorbent assay. Pearson correlation analysis was performed for the correlation between AQP4 and S100β, and the values of AQP4 and S100β in prediction of infectious hydrocephalus were analyzed by means of receiver operating characteristic (ROC) curves. RESULTS The expression levels of AQP4 and S100β of the infection group were significantly higher than those of the no infection group; the scores of acute physiology and chronic health evaluation (APACHEⅡ) and visual analogue scale (VAS) of the infection group were significantly higher than those of the no infection group(P＜0.05). Among the patients with infectious hydrocephalus, APACHEⅡ was positively correlated with VAS,and AQP4 was positively correlated with S100β (P＜0.05). The expression levels of S100β and AQP4 of the patients with severe infectious hydrocephalus were significantly higher than those of the patients with mild infectious hydrocephalus (P＜0.05). ROC curve analysis showed that the value of the joint detection of AQP4 and S100β was significantly higher than that of the single detection in prediction of infectious hydrocephalus (P＜0.05). CONCLUSION The patients with infectious hydrocephalus show abnormal rise of expressions of AQP4 and S100β, which can be used as genetic test indexes for infectious hydrocephalus.