Pathogens isolated from chronic renal failure hemodialysis patients with catheter-associated infection and risk factors

OBJECTIVE To investigate the pathogens isolated from the chronic renal failure hemodialysis patients with catheter-associated infection and analyze the risk factors. METHODS A total of 405 chronic renal failure patients who underwent hemodialysis in the Fourth People's Hospital of Haikou and the Second Affiliated Hospital of Hainan Medical College from Jun 2018 to Dec 2022 were enrolled in the study, and the clinical data were retrospectively collected from the patients. The distribution of the pathogens isolated from the chronic renal failure hemodialysis patients with catheter-associated infection was statistically analyzed. Univariate analysis and multivariate logistic regression analysis were performed for the risk factors for the infection. RESULTS Totally 64 patients had catheter-associated infection among the 405 chronic renal failure hemodialysis patients; 72 strains of pathogens were isolated, 28 of which were gram-negative bacteria, and 44 were gram-positive bacteria; Pseudomonas aeruginosa was the predominant species of the gram-negative bacteria, and Staphylococcus aureus was dominant among the gram-positive bacteria. Complication with diabetes mellitus, catheter indwelling time, types of catheter, dialysis duration, hemoglobin and albumin were the risk factors for the catheter-associated infection in the chronic renal failure hemodialysis patients(P<0.05). CONCLUSION P.aeruginosa and S.aureus are the predominant species of pathogens isolated from the chronic renal failure hemodialysis patients with catheter-associated infection. The risk factors include the complication with diabetes mellitus, catheter indwelling time more than 14 days, temporary catheter, dialysis duration no less than 1 year, hemoglobin no more than 90 g/L and albumin less than 30 g/L.