OBJECTIVE To investigate serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) with to ceruloplasmin (CER) and red blood cell distribution width (RDW) in patients with postoperative colon cancer infection and its diagnostic value, and to provide references for early diagnosis of the disease.
METHODS Seventy-three patients with postoperative colon cancer infections in First Affiliated Hospital of Huzhou Normal University from Oct. 2019 to Jan. 2022 were selected as the study group, and 73 patients without postoperative infections during the same period were selected as the control group according to the principle of 1∶1 ratio, and sTREM-1, CER, and RDW levels were measured. The sTREM-1, CER, RDW levels and acute physiological and chronic health status scale Ⅱ(APACHEⅡ) scores were compared between the two groups, multivariate logistic regression analysis model was used to analyze the correlation between sTREM-1, CER, RDW levels and infections after colon cancer, Pearson analysis was used to analyze the correlation between each index level and APACHEⅡ score, and the receiver operating characteristic (ROC) curve was used to explore the diagnostic efficacy of each indicator for postoperative infection in colon cancer The level of the above indicators in the infection-controlled patients versus the infection-uncontrolled patients were analyzed.
RESULTS The levels of sTREM-1, CER, RDW, and APACHE Ⅱ score in the study group were (58.56±10.31) pg/ml, (464.80±61.44) mg/L, (16.38±2.30)%, and (21.26±3.69) points, respectively, which were higher than those in the control group (P < 0.05). The levels of sTREM-1, CER, and RDW were positively correlated with the APACHE Ⅱ score (r=0.705, 0.690, 0.687, all P < 0.05). The postoperative infection of colon cancer was significantly correlated with sTREM-1, CER, and RDW (P < 0.05). The area under the curve of CER for diagnosing postoperative infection in colon cancer patients was 0.813, which was higner than that of sTREM-1 and RDW, with the optimal diagnostic sensitivity of 86.30%, and the specificity of 65.75%. The pretreatment sTREM-1, CER, and RDW in the infection-controlled patients were (38.81±10.30) pg/ml, (313.56±56.10) mg/L, and (11.93±2.10)%, respectively, which were lower than those in the infection-uncontrolled patients (P < 0.05).
CONCLUSION Abnormally elevated expression of sTREM-1, CER, and RDW in patients with postoperative infection of colon cancer is closely related to the occurrence of infection and positively correlates with the severity of the patient′s condition, which has certain value in the diagnosis of postoperative infection of colon cancer.
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