Levels of coagulation and inflammatory indexes in patients with nosocomial infections after total hysterectomy

OBJECTIVE To explore levels of coagulation and inflammatory indexes in nosocomial infections after total hysterectomy, and to provide reference for the prevention of postoperative infections.

METHODS A total of 142 patients undergoing laparoscopic total hysterectomy in Linping District First People′s Hospital, Hangzhou between Jul. 2020 and Oct. 2023 were selected and were divided into an infection group of 15 cases and a non-infection group of 127 cases according to the presence or absence of nosocomial infection within 7d after surgery. The peripheral blood coagulation indexes thrombin time (TT), prothrombin time (PT), fibrinogen (FIB) and activated partial thromboplastin time (APTT) and inflammatory indexes tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP) and procalcitonin (PCT) in the two groups were compared before and after surgery.

RESULTS The coagulation function indexes APTT, PT and TT time of the two groups were shorter after the surgery for 1 day than before the surgery, and the FIB level was higher after the surgery for 1 days than before the surgery, and the FIB level of the infection group was higher than that of the no infection group (P < 0.05). After surgery, levels of serum IL-6, TNF-α, PCT and hs-CRP were increased in both groups, which were higher in the infection group than those in the non-infection group (P < 0.05). Compared with 1 d after surgery, the coagulation function indexes APTT, PT and TT were prolonged and FIB levels was decreased at 3 d and 7 d after surgery in the infection group, and APTT, PT and TT time was shortened, and FIB levels was increased in the non-infection group. At 3 d and 7 d after surgery, APTT, PT and TT in the infection group were longer than those in the non-infection group, and FIB was lower than that in the non-infection group (P < 0.05). Compared with those at 1 d after surgery, levels of serum IL-6, TNF-α, PCT and hs-CRP were increased in the infection group at 3 d and 7 d after surgery, which were decreased in the non-infection group. At 3 d and 7 d after surgery, levels of serum IL-6, TNF-α, PCT and hs-CRP in the infection group were higher than those in the non-infection group (P < 0.05).

CONCLUSION The risk of nosocomial infection is high after total hysterectomy, which can lead to disturbances of the body′s coagulation function and an increased inflammatory response.