OBJECTIVE To analyze the clinical distribution characteristics and drug resistance of Enterobacter cloacae in Gansu Province from 2019 to 2023, providing reference for the prevention and control of E.cloacae infections in this region.
METHODS Data on the distribution and drug resistance of E.cloacae from hospitals in member units of the Gansu Antimicrobial Surveillance Network between 2019 and 2023 were collected.In vitro drug susceptibility testing was performed by the Kirby-Bauer disk diffusion (K-B) method, minimum inhibitory concentration method, and fully automated instrumentation, followed by analysis of the susceptibility results.
RESULTS From 2019 to 2023, a total of 402 490 bacterial strains were isolated and cultured in Gansu Province, including 17 417 strains of E.cloacae, with a detection rate of 4.33%.The bacteria were primarily isolated from sputum specimens (62.81%), followed by urine (7.37%) and wound pus specimens (6.07%).The departmental distribution was dominated by internal medicine (44.96%) and surgery (28.50%).The highest detection rate was observed in the adult group (15-65 years, 45.79%).E.cloacae exhibited varying degrees of resistance to over 20 antibacterial drugs, but the overall drug resistance rate showed a declining trend (P < 0.05).The highest drug resistance rate was observed for cefazolin (96.40%-98.38%), while the lowest was for tigecycline (0.44%-2.92%).Carbapenem-resistant E.cloacae demonstrated an increasing trend in drug resistance rates, with imipenem resistance ranging from 2.79% to 3.71%(P=0.044) and meropenem resistance ranging from 1.29% to 3.41%(P < 0.05).
CONCLUSIONS The isolation rate of E.cloacae in Gansu Province remains stable, with a declining trend in drug resistance to multiple antibacterial drugs.However, the increasing drug resistance to carbapenems warrants attention.
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