OBJECTIVE To investigate the relationship between microbial culture results of donor kidney lavage fluid, arterial valves and kidney transplant recipient drainage fluid and postoperative infection.
METHODS Clinical data of 227 kidney transplant recipients at the First People′s Hospital of Changzhou from Jan. 2021 to Dec. 2024 were retrospectively analyzed. Based on culture results of donor kidney lavage fluid, arterial valves and recipient drainage fluid, patients were divided into positive and negative groups. Pathogenic bacterium distribution, postoperative infection rates, hospital stays and other indicators were analyzed.
RESULTS The positive culture rate of donor kidney lavage fluid and arterial valves was 26.43% (60 cases), with 80 bacterial strains detected, predominantly gram-positive bacteria (55.00%), gram-negative bacteria (35.00%) and fungi (10.00%). However, no significant difference in postoperative infection rates was observed between the positive and negative groups (P=0.109). Recipient drainage fluid cultures were mainly gram-negative bacteria. Infection rates at the 1 st, 2nd and 3rd week after surgery for positive patients were 22.45%, 30.48% and 53.42%, respectively (P=0.001), increasing with prolonged positivity. Patients with persistent positivity at the third week had prolonged hospital stays (31.75 d vs. 23.36 d), duration of antibacterial drug use (30.62 d vs. 23.27 d) and catheterization time (P < 0.05).
CONCLUSIONS Culture results of donor kidney lavage fluid and arterial valves show no significant correlation with postoperative infection but may serve as early warnings for multidrug-resistant bacteria or fungal infection. Positive recipient drainage fluid cultures, especially persistent positivity at the third week after surgery, are significantly associated with infection risk and prolonged hospital stay, which should be taken as key monitoring indicators for infection prevention and control.
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